The field of scientific interests of the laboratory staff is versatile and includes high-performance computing, supercomputers, ensuring the performance of supercomputer centers, parallel programming technologies, lists of the most powerful supercomputers, performance testing methods, mathematical program models, applications optimization, static and dynamic program analysis methods, program performance visualization, tools for developing parallel applications, supercomputer monitoring systems, performance metrics of the supercomputer as a whole and its individual components, supercomputer administration tools, parallel application analysis tools, dynamic program characteristics analysis, algorithm structure description, parallel application efficiency, algorithms and programs scalability, data and computation locality, supercomputer task flow analysis, formal methods for describing the architecture of parallel computers, supercomputer infrastructure, Internet and training, supercomputing education, training courses on parallel computing, metacomputing and GRID technologies, creation of Web services and mobile applications, organization of supercomputer conferences and seminars.